GI Symptoms
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Learn About GI Symptoms & Leaky Gut
Learn about the conditions & symptoms affecting your life at iLabMD. Schedule a consultation with us to learn how we can help guide your healthcare. We offer an alternative to traditional medicine with our functional health approach.
Gut Disfunction
Gut dysfunction can be responsible for GI conditions, such as constipation, diarrhea, abdominal pain, gas, bloating, acid reflux, indigestion, Irritable Bowel Disease (IBS), Inflammatory Bowel Disease (IBD).
Gut Microbiota & Health
About 95% of the body’s symbiotic microbes are found in the gut. In a balanced state, this diverse population of microbiota promotes overall health. However, when the gut reaches a state of dysbiosis (imbalance), it can lead to various diseases.
Gut Dysbiosis
Gut dysbiosis has been associated with a wide range of diseases and health conditions. While it doesn’t necessarily cause these conditions directly, it can contribute to their development or exacerbate existing symptoms.
It's important to note that the relationship between gut dysbiosis and these conditions is complex and multifactorial. While research continues to uncover associations, causality is often challenging to establish definitively. Additionally, the gut microbiome is highly individualized, and what constitutes "normal" or "healthy" can vary among individuals.
Gut Health Testing
Includes GI-MAP with Zonulin by Diagnostic Solutions (used for diagnosis and / or monitoring of IBS, GI issues (diarrhea, constipation, GERD), brain fog, autoimmune diseases, skin issues (rash, dermatitis, acne), mood disorders (depression, anxiety), diabetes, weight loss issues.
The GUT HEALTH test that we offer utilizes up-to-date comprehensive GI tests that study, analyze and quantify various components of GI system, that include the following:
Harmful bacteria, parasites and viruses, including Clostridium difficile, E.coli, Campylobacter, Cryptosporidium, and many more)
H.Pylori (multiple strands) that have been shown to cause gastritis, stomach cancer and ulcers.
Commensal Beneficial Bacteria: these bacteria are responsible for preservation of gut barrier and protect against toxins.
Commensal Harmful Bacterial: these bacteria only cause disease in some people, especially in immune-compromised population. The higher is the burden of these bacteria, the more likely they are to cause gut inflammation. These bacteria include Pseudomonas, Enterococcus, various strands of Staphylococcus and more.
Inflammatory and Autoimmune related bacteria
Fungi: Fungi are common in GI tract, but it is their overgrowth that can lead to variety of symptoms.
Viruses: Cytomegalovirus and EBV
Parasites, including worms
GI markers for DIGESTION, INFLAMMATION, and IMMUNITY, such as Fecal fat, beta-glucuronidase, various IgA, Calprotectin and more.
Zonulin, a marker of leaky gut, is included in this test
We use state-of-the arts functional medicine GI tests, such as GI-MAP (Diagnostic Solutions) link, GI Effects Comprehensive (Genova) and more.
Learn More & Get Answers To FAQs
The gut plays a crucial role in the production of serotonin, a neurotransmitter and hormone that influences various bodily functions, including mood, appetite, and digestion. Approximately 90% of serotonin is found in the cells of the gastrointestinal tract, particularly in enterochromaffin cells in the intestinal lining.
The process of serotonin production in the gut involves the conversion of the amino acid tryptophan into serotonin. Several key steps are involved:
It’s important to note that while the gut is a significant source of serotonin, the brain also produces serotonin, and there is a complex interplay between the gut and the brain in serotonin regulation. The gut-brain axis is a bidirectional communication system that involves the central nervous system (CNS) and the enteric nervous system (ENS) within the gastrointestinal tract. Changes in gut health and microbiome composition can influence serotonin production and signaling, potentially impacting mood and mental health.
Serotonin is also involved in regulating peristalsis (the movement of the digestive tract), secretion of digestive enzymes, and other gastrointestinal functions. Imbalances in serotonin levels in the gut can contribute to digestive disorders such as irritable bowel syndrome (IBS) and may play a role in mood disorders like depression and anxiety. Researchers continue to explore the intricate connections between gut health, serotonin production, and overall well-being.
The functions of the gut include digestion, absorption, immune protection, microbial balance and “neurocommunication”.
Gut mucosa (inner lining) is the largest protective organ of the body, measuring about about 430 square feet.
Impairments in gut absorption and digestion can lead to a range of digestive problems and nutritional deficiencies. Here are some common issues related to impaired gut absorption and digestion:
Malabsorption Syndromes: Conditions like celiac disease, Crohn’s disease, and chronic pancreatitis can impair the body’s ability to absorb nutrients properly. Celiac disease, for example, involves an autoimmune reaction to gluten that damages the lining of the small intestine, leading to malabsorption of nutrients.
Lactose Intolerance: This condition occurs when the body lacks the enzyme lactase, which is needed to digest lactose, a sugar found in milk and dairy products. Without enough lactase, undigested lactose can lead to bloating, gas, and diarrhea.
Poor mastication (chewing): Poor mastication, which refers to inadequate chewing of food, can lead to several gut problems and overall digestive issues. Proper chewing is a crucial part of the digestion process as it breaks down food into smaller particles, mixes it with saliva, and prepares it for further digestion in the stomach and intestines. Here are some gut problems that can arise from poor mastication:
Pancreatic Insufficiency: The pancreas produces enzymes that are crucial for the digestion of fats, proteins, and carbohydrates. Conditions that affect the pancreas, such as chronic pancreatitis or pancreatic cancer, can lead to insufficient enzyme production, impairing digestion.
Bile Duct Disorders: The liver produces bile, which is stored in the gallbladder and released into the small intestine to aid in the digestion and absorption of fats. Blockages or disorders of the bile ducts can disrupt this process.
Hypochlorhydria: Hypochlorhydria is a condition characterized by abnormally low levels of stomach acid, or hydrochloric acid, in the stomach. Stomach acid plays a crucial role in the digestive process by breaking down food, sterilizing it to kill harmful bacteria, and facilitating the absorption of certain nutrients. When the stomach produces insufficient acid, it can lead to a range of digestive problems. Here are some key points about hypochlorhydria:
Small Intestinal Bacterial Overgrowth (SIBO): SIBO occurs when there is an abnormal increase in the number or types of bacteria in the small intestine. This can interfere with the absorption of nutrients and lead to symptoms like diarrhea, bloating, and nutrient deficiencies.
Gastric Surgery: Certain weight loss surgeries, such as gastric bypass or sleeve gastrectomy, alter the anatomy of the digestive tract. While effective for weight loss, these procedures can affect nutrient absorption and require careful monitoring and supplementation.
Medications: Some medications, such as proton pump inhibitors (PPIs) used to reduce stomach acid, can affect digestion and nutrient absorption when used for extended periods.
Food Allergies: Allergic reactions to certain foods can lead to inflammation and damage to the gut lining, affecting nutrient absorption.
Aging: As people age, digestive function can naturally decline, leading to reduced enzyme production and absorption capacity.
Treatment and management of impaired gut absorption and digestion depend on the underlying cause. It may involve dietary changes, enzyme replacement therapy, medications, or surgery. If you suspect you have issues with gut absorption or digestion, it’s important to consult a healthcare professional for a proper diagnosis and treatment plan.
Decreased intestinal permeability, or leaky gut has been found to be the root cause of many diseases.
Leaky gut syndrome, also known as increased intestinal permeability, is a condition where the lining of the small intestine becomes more porous than normal, allowing undigested food particles, toxins, and bacteria to leak into the bloodstream. This condition is not widely recognized by the medical community, and its exact causes and effects are still a subject of ongoing research. However, here are some key points about leaky gut:
Intestinal Barrier: The lining of the small intestine is responsible for absorbing nutrients from food while acting as a barrier to prevent harmful substances from entering the bloodstream. In a healthy gut, tight junctions between cells keep this barrier intact.
Leaky Gut Symptoms: Leaky gut is often associated with a range of symptoms, including digestive issues (bloating, gas, diarrhea), food sensitivities, allergies, skin problems, fatigue, and even mood disorders. However, these symptoms can be non-specific and overlap with other conditions.
Potential Causes: The causes of leaky gut are not fully understood, but they may include chronic stress, a poor diet high in processed foods, excessive alcohol consumption, the use of nonsteroidal anti-inflammatory drugs (NSAIDs), certain infections, and genetic factors.
Dietary Factors: Certain dietary factors, such as gluten and dairy, can contribute to intestinal permeability in susceptible individuals.
Treatment: Managing leaky gut often involves addressing underlying factors such as reducing stress, improving diet, and addressing any identified food sensitivities. Probiotics and supplements play a significant role in the treatment.
Decreased intestinal permeability, or leaky gut has been found to be the root cause of many diseases.
Leaky gut syndrome, also known as increased intestinal permeability, is a condition where the lining of the small intestine becomes more porous than normal, allowing undigested food particles, toxins, and bacteria to leak into the bloodstream. This condition is not widely recognized by the medical community, and its exact causes and effects are still a subject of ongoing research. However, here are some key points about leaky gut:
Intestinal Barrier: The lining of the small intestine is responsible for absorbing nutrients from food while acting as a barrier to prevent harmful substances from entering the bloodstream. In a healthy gut, tight junctions between cells keep this barrier intact.
Leaky Gut Symptoms: Leaky gut is often associated with a range of symptoms, including digestive issues (bloating, gas, diarrhea), food sensitivities, allergies, skin problems, fatigue, and even mood disorders. However, these symptoms can be non-specific and overlap with other conditions.
Potential Causes: The causes of leaky gut are not fully understood, but they may include chronic stress, a poor diet high in processed foods, excessive alcohol consumption, the use of nonsteroidal anti-inflammatory drugs (NSAIDs), certain infections, and genetic factors.
Dietary Factors: Certain dietary factors, such as gluten and dairy, can contribute to intestinal permeability in susceptible individuals.
Treatment: Managing leaky gut often involves addressing underlying factors such as reducing stress, improving diet, and addressing any identified food sensitivities. Probiotics and supplements play a significant role in the treatment.
The human microbiome is home to trillions of microorganisms, primarily bacteria. While the exact number can vary from person to person, it’s estimated that there are approximately 100 trillion bacteria in the human microbiome. These bacteria inhabit various parts of the body, with the largest populations found in the gut, where they play essential roles in digestion, immunity, and overall health. The microbiome also includes other microorganisms such as viruses, fungi, and archaea, but bacteria are the most abundant and well-studied component.
WHAT CAN AFFECT GUT MICROBIOME?
The composition of the gut microbiome can be influenced by a variety of factors. It’s a dynamic ecosystem that can change over time in response to both internal and external influences. Here are some key factors that can impact the gut microbiome:
Diet: The type and quantity of food you eat have a significant impact on your gut microbiome. A diet rich in fiber, fruits, vegetables, and fermented foods can promote a diverse and healthy microbiome. Conversely, a diet high in processed foods, sugars, and saturated fats may lead to an imbalance in gut bacteria.
Antibiotics: Antibiotics are designed to kill harmful bacteria, but they can also affect beneficial bacteria in the gut. Overuse or misuse of antibiotics can disrupt the balance of the microbiome and lead to dysbiosis.
Probiotics: Taking probiotic supplements or consuming probiotic-rich foods (e.g., yogurt, kefir) can introduce specific strains of beneficial bacteria to the gut and potentially influence the microbiome.
Stress: Chronic stress can impact the gut-brain axis and alter the composition of the gut microbiome. Stress management techniques may help mitigate these effects.
Illness and Infections: Gastrointestinal infections and certain medical conditions can temporarily disrupt the gut microbiome. Recovery often involves restoring balance through diet, medications, or medical treatment.
Age: The gut microbiome can change with age. Infants have a different microbiome composition than adults, and the elderly may experience changes as well.
Lifestyle Factors: Smoking, alcohol consumption, and lack of physical activity can influence the gut microbiome.
Environmental Exposures: Environmental factors, such as exposure to pollutants or toxins, can affect the gut microbiome.
Genetics: Genetics play a role in determining the initial composition of your microbiome, but it can still be modified by other factors.
Medical Treatments: Certain medical treatments, such as chemotherapy or radiation therapy, can affect the gut microbiome. Healthcare providers may take steps to manage these effects.
Disease and Conditions: Some diseases and conditions, like inflammatory bowel disease (IBD) or irritable bowel syndrome (IBS), are associated with alterations in the gut microbiome.
It’s important to note that the gut microbiome is highly individualized, and what influences one person’s microbiome may not have the same effect on another’s. Additionally, research on the gut microbiome is ongoing, and our understanding of its complexity and its role in health and disease continues to evolve. Maintaining a balanced and diverse microbiome through a healthy diet and lifestyle choices is generally considered beneficial for overall health.
Dysfunction or imbalance in the gut microbiome, a condition known as dysbiosis, has been associated with various health issues and diseases. While a direct cause-and-effect relationship is not always clear, research suggests that an unhealthy gut microbiome may contribute to the development or exacerbation of certain conditions. Here are some diseases and health problems that have been linked to gut microbiome dysfunction.
Inflammatory Bowel Disease (IBD): Conditions like Crohn’s disease and ulcerative colitis are characterized by chronic inflammation of the gut. Dysbiosis in the gut microbiome is thought to play a role in the development and progression of these diseases.
Irritable Bowel Syndrome (IBS): IBS is a functional gastrointestinal disorder that can cause abdominal pain, bloating, and changes in bowel habits. Alterations in the gut microbiome have been observed in some individuals with IBS.
Obesity: Research has suggested a potential link between gut microbiome composition and obesity. An imbalance in the microbiome may affect how the body processes and stores calories.
Type 2 Diabetes: Some studies have shown differences in the gut microbiome between individuals with type 2 diabetes and those without the condition. The microbiome may influence glucose metabolism and insulin sensitivity.
Autoimmune Diseases: Dysbiosis has been associated with various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. Changes in the gut microbiome may trigger or exacerbate autoimmune responses.
Allergies and Asthma: Altered gut microbiome composition has been linked to an increased risk of allergies and asthma, particularly in children.
Mental Health Disorders: The gut-brain axis is a bidirectional communication system between the gut and the brain. Dysbiosis may influence mental health conditions such as depression, anxiety, and even neurodevelopmental disorders like autism.
Cardiovascular Disease: Emerging research suggests a possible connection between gut microbiome imbalances, inflammation, and cardiovascular disease risk factors.
Liver Diseases: Conditions like non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) have been associated with changes in the gut microbiome.
Colon Cancer: Dysbiosis may contribute to an increased risk of colorectal cancer by influencing inflammation and the production of certain metabolites.
It’s important to emphasize that while these associations are being explored, causation is often complex and may involve multiple factors. Additionally, the gut microbiome is highly individualized, and what may be detrimental for one person’s microbiome may not be the same for another’s.
Research in this field is ongoing, and our understanding of the gut microbiome’s role in health and disease continues to evolve. Maintaining a healthy gut microbiome through a balanced diet, regular exercise, and other lifestyle factors is generally considered beneficial for overall health.
The neuroenteric mechanism of the gut refers to the complex network of nerves and neurons that control the functioning of the gastrointestinal (GI) tract. This system plays a crucial role in regulating various digestive processes, including peristalsis (the movement of food through the digestive tract), secretion of digestive juices, and the coordination of various digestive functions.
Here are some key points about the neuroenteric mechanism of the gut:
Enteric Nervous System (ENS): The ENS is often referred to as the “second brain” of the body because it consists of a vast network of neurons located within the walls of the digestive tract. It operates independently of the central nervous system (the brain and spinal cord) but can communicate with it.
Intrinsic Control: The ENS can function autonomously, meaning it can regulate GI functions without input from the central nervous system. It can sense the presence of food, control muscle contractions, and coordinate the release of digestive enzymes and hormones.
Extrinsic Control: While the ENS can operate independently, it also receives input from the central nervous system through extrinsic nerves. The vagus nerve, for example, plays a role in transmitting signals from the brain to the gut and vice versa.
Reflexes: The ENS can generate reflexes in response to various stimuli. For example, the gastrocolic reflex triggers an increase in motility in the colon after eating, helping to move waste along.
Communication: The ENS communicates with the central nervous system and other parts of the body via neurotransmitters and hormones. It can influence emotions and stress responses and is closely linked to the gut-brain axis.
Disorders: Dysfunctions in the neuroenteric mechanism of the gut can lead to digestive disorders like irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). These conditions can result from abnormalities in the ENS or its communication with the central nervous system.
Understanding the neuroenteric mechanism of the gut is essential for comprehending how the digestive system functions and how it can be affected by various factors, including stress, diet, and neurological conditions.
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